After being shrunk by a shrinking machine and ending up on a dog having a bubble bath, Alexander, his cousin Judy, and a tiny robot try to survive encounters with insects, soapy bubbles, and bathtub and toilet drains.

When ten-year-old Andrew invents a shrinking machine, he does not expect to be sucked into the machine along with his cousin Judy, only to end up in a dog's nose.

While bouncing through Earth's prehistory in a malfunctioning time machine, Andrew, his cousin Judy, and Thudd the robot meet Dr. Kron-Tox's nephew, Beeper, and nearly lose the Time-a-Tron in a tsunami.

When an electric fish shrinks Andrew, Judy, and Thudd to the size of bacteria, they end up being injected by a mosquito into Uncle Al's bloodstream where they must battle germs, parasites, and white blood cells.